Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline

MediHelp rates the interaction as moderate. Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.

MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.