Drug interactions
Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline
Severity: Moderate
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.
What this interaction means in plain words
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic suppression of colonic bacteria needed to convert picosulfate to its active metabolite.
What to do
Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tigecycline
- Tigecycline + Typhoid vaccine live Major
- Bcg vaccine live + Tigecycline Moderate
- Cholera vaccine + Tigecycline Moderate
- Microbiota + Tigecycline Moderate
- Mipomersen + Tigecycline Moderate
- Balsalazide + Tigecycline Minor
Frequently asked questions
Can I take Sodium picosulfate / magnesium oxide / anhydrous citric acid with Tigecycline?
MediHelp rates the interaction as moderate. Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics may reduce the bowel-cleansing effect of picosulfate preparations by disrupting the colonic bacteria that activate it. The magnesium component could also bind some drugs, although tigecycline is given intravenously so a chelation effect is unlikely to be significant.
How serious is the interaction between Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tigecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm adequate bowel cleansing before the procedure and consider a different preparation if antibiotic therapy cannot be avoided. Do not rely on timing separation, since tigecycline is given intravenously.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
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