Référentiel des médicaments
Aztreonam
Aztreonam is a medicine in the class anti bacterial. It is used for cystic fibrosis.
- Classe médicamenteuse: Anti Bacterial
- Indications: cystic fibrosis
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Anti Bacterial
- Code ATC
- J01DF01
- Formes courantes
- injection
- Dosages courants
- 1 g, 500 mg
- Interactions connues
- 16 (Modérée: 5 · Mineure: 11)
- Noms commerciaux
- 5
- Pays et marchés
- 3
Indications
Mécanisme d'action
Monobactam; inhibits cell wall synthesis by binding to penicillin binding proteins
Posologie adulte habituelle (résumé de la notice)
Systemic Infections (Moderately severe): 1-2 g IV/IM q8-12hr; not to exceed 8 g/day
Grossesse et allaitement
- Grossesse
- Safe Crosses the placenta; animal studies showed no harm and limited human use has not shown problems. As a beta-lactam it is an acceptable option when a serious gram-negative infection needs treatment.
- Allaitement
- Safe Milk levels are under 1% of maternal blood levels and it is poorly absorbed from the infant gut. US label suggests considering a temporary pause; LactMed: acceptable. Watch for diarrhoea or thrush. Inhaled aztreonam gives even lower exposure.
Effets indésirables signalés
- Cough
- Fever
- Nasal congestion
- Sore throat
- Wheezing
Précautions particulières
- May cause bronchospasm, stop treatment if chest tightness develops during nebulizer use
- In patients with impaired hepatic or renal function, appropriate monitoring is recommended during therapy
- If aminoglycoside is used concurrently, especially if high dosages of former are used or if therapy is prolonged, renal function should be monitored
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (16)
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
- Amoxicillin + Aztreonam Minor
- Amoxicillin-clavulanic acid + Aztreonam Minor
- Aztreonam + Bcg vaccine live Minor
- Aztreonam + Cefpirome Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Aztreonam used for?
Aztreonam is a medicine in the class anti bacterial. It is used for Cystic fibrosis, Pseudomonal infections, Sepsis, Urinary tract infections.
What side effects have been reported with Aztreonam?
Cough, Fever, Nasal congestion, Sore throat, Wheezing.
Can Aztreonam be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Crosses the placenta; animal studies showed no harm and limited human use has not shown problems. As a beta-lactam it is an acceptable option when a serious gram-negative infection needs treatment. Breastfeeding: Safe. Milk levels are under 1% of maternal blood levels and it is poorly absorbed from the infant gut. US label suggests considering a temporary pause; LactMed: acceptable. Watch for diarrhoea or thrush. Inhaled aztreonam gives even lower exposure.
What does Aztreonam interact with?
MediHelp lists 16 known interactions for Aztreonam. Moderate: 5 · Minor: 11. The most serious include Cefoxitin, Cholera vaccine, Microbiota.
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