Référentiel des médicaments
Elacestrant
Elacestrant is a medicine in the class oncology. It is used for breast cancer.
- Classe médicamenteuse: Oncology
- Indications: breast cancer
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Oncology
- Formes courantes
- comprimé
- Interactions connues
- 50 (Majeure: 20 · Modérée: 23 · Mineure: 7)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Elacestrant is an estrogen receptor antagonist that binds to ERα and inhibits estradiol-mediated proliferation of ER+ HER2- breast cancer cells, with degradation of ERα protein via the proteasomal pathway.
Posologie adulte habituelle (résumé de la notice)
ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer: 345 mg orally with food once daily until disease progression or unacceptable toxicity
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm: in rats it caused embryo-fetal death and limb and skull malformations below human exposure; no human data. Verify pregnancy status first. Women, and men with female partners, should use effective contraception during treatment and for 1 week after.
- Allaitement
- Unsafe No data on milk levels. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
Effets indésirables signalés
- Musculoskeletal pain
- Nausea
- Increased cholesterol
- Increased AST
- Increased triglycerides
- Fatigue
Précautions particulières
- Dyslipidemia: hypercholesterolemia and hypertriglyceridemia may occur; monitor lipid profile before starting and periodically.
- Embryo-fetal toxicity: can cause fetal harm; advise effective contraception during treatment and for 1 week after the last dose.
- May impair fertility in females and males of reproductive potential.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (50)
- Amobarbital + Elacestrant Major
- Apalutamide + Elacestrant Major
- Aprepitant + Elacestrant Major
- Armodafinil + Elacestrant Major
- Carbamazepine + Elacestrant Major
- Clarithromycin + Elacestrant Major
- Efavirenz + Elacestrant Major
- Elacestrant + Enzalutamide Major
- Elacestrant + Erythromycin Major
- Elacestrant + Eslicarbazepine Major
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Questions fréquentes
What is Elacestrant used for?
Elacestrant is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Elacestrant?
Musculoskeletal pain, Nausea, Increased cholesterol, Increased AST, Increased triglycerides, Fatigue.
Can Elacestrant be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats it caused embryo-fetal death and limb and skull malformations below human exposure; no human data. Verify pregnancy status first. Women, and men with female partners, should use effective contraception during treatment and for 1 week after. Breastfeeding: Unsafe. No data on milk levels. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
What does Elacestrant interact with?
MediHelp lists 50 known interactions for Elacestrant. Major: 20 · Moderate: 23 · Minor: 7. The most serious include Amobarbital, Apalutamide, Aprepitant.
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