Interactions médicamenteuses
Clarithromycin + Elacestrant
Gravité: Majeure
Clarithromycin and Elacestrant: major interaction.
Dernière mise à jour
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Résumé
Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
Ce que signifie cette interaction, en termes simples
Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Elacestrant belongs to Oncology.
Pourquoi elle survient
Clarithromycin inhibits CYP3A4, the main metabolic pathway of elacestrant.
Conduite à tenir
Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Clarithromycin
- Astemizole + Clarithromycin Contre-indiquée
- Avanafil + Clarithromycin Contre-indiquée
- Cisapride + Clarithromycin Contre-indiquée
- Clarithromycin + Colchicine Contre-indiquée
- Clarithromycin + Conivaptan Contre-indiquée
- Clarithromycin + Dihydroergotamine Contre-indiquée
Autres interactions de Elacestrant
- Amobarbital + Elacestrant Majeure
- Apalutamide + Elacestrant Majeure
- Aprepitant + Elacestrant Majeure
- Armodafinil + Elacestrant Majeure
- Carbamazepine + Elacestrant Majeure
- Efavirenz + Elacestrant Majeure
Questions fréquentes
Can I take Clarithromycin with Elacestrant?
MediHelp rates the interaction as major. Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Elacestrant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
