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Interactions médicamenteuses

Elacestrant + Enzalutamide

Gravité: Majeure

Elacestrant and Enzalutamide: major interaction.

Dernière mise à jour

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Résumé

Strong CYP3A inducers reduce elacestrant exposure and may compromise its efficacy in breast cancer. Enzalutamide is expected to have this effect.

Ce que signifie cette interaction, en termes simples

Elacestrant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Elacestrant belongs to Oncology; Enzalutamide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 induction by enzalutamide accelerates elacestrant metabolism.

Conduite à tenir

Avoid coadministration; labeling recommends avoiding strong and moderate CYP3A inducers. Choose an alternative therapy where possible.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Elacestrant with Enzalutamide?

MediHelp rates the interaction as major. Elacestrant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A inducers reduce elacestrant exposure and may compromise its efficacy in breast cancer. Enzalutamide is expected to have this effect.

How serious is the interaction between Elacestrant and Enzalutamide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; labeling recommends avoiding strong and moderate CYP3A inducers. Choose an alternative therapy where possible.

What other medicines interact with Enzalutamide?

MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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