Référentiel des médicaments
Fostemsavir
Fostemsavir is a medicine in the class anti virals. It is used for hiv.
- Classe médicamenteuse: Anti Virals
- Indications: hiv
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Anti Virals
- Formes courantes
- comprimé
- Dosages courants
- 600 mg
- Interactions connues
- 157 (Contre-indiquée: 6 · Majeure: 5 · Modérée: 114 · Mineure: 32)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
HIV-1 gp120-directed attachment inhibitor; HIV-1 antiretroviral agent. Fostemsavir is a prodrug of temsavir, the active moiety.
Posologie adulte habituelle (résumé de la notice)
HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 (with other antiretrovirals): 600 mg tablet orally twice daily with or without food
Grossesse et allaitement
- Grossesse
- Unknown Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control.
- Allaitement
- Unknown Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
Effets indésirables signalés
- Nausea
- Diarrhea
- Headache
- Abdominal pain
- Dyspepsia
- Fatigue
Contre-indications
- Previous hypersensitivity to fostemsavir or any component of the formulation.
- Coadministration with strong CYP3A inducers (e.g., enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, St John's wort) because of loss of virologic response.
Précautions particulières
- Immune reconstitution syndrome, including inflammatory responses to opportunistic infections and autoimmune disorders, has been reported.
- QTc prolongation seen at higher than recommended doses; use caution with history of QT prolongation, cardiac disease, or drugs with Torsade de Pointes risk.
- Hepatic transaminase elevations in HBV/HCV co-infection, including hepatitis B reactivation; monitor liver chemistries.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (157)
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Efavirenz + Fostemsavir Major
- Fostemsavir + Lorlatinib Major
- Fostemsavir + Pimozide Major
- Fostemsavir + Sofosbuvir-velpatasvir-voxilaprevir Major
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- Renal and hepatic dose adjustments
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- Patient counselling points
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Questions fréquentes
What is Fostemsavir used for?
Fostemsavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Fostemsavir?
Nausea, Diarrhea, Headache, Abdominal pain, Dyspepsia, Fatigue.
Can Fostemsavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control. Breastfeeding: Unknown. Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
What does Fostemsavir interact with?
MediHelp lists 157 known interactions for Fostemsavir. Contraindicated: 6 · Major: 5 · Moderate: 114 · Minor: 32. The most serious include Apalutamide, Carbamazepine, Enzalutamide.
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