Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Enzalutamide + Fostemsavir

Gravité: Contre-indiquée

Enzalutamide and Fostemsavir: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Fostemsavir's active moiety temsavir is a CYP3A4 substrate, and strong inducers substantially lower its concentrations. Labeling contraindicates the combination because of loss of virologic response and resistance.

Ce que signifie cette interaction, en termes simples

Enzalutamide and Fostemsavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Enzalutamide belongs to Endocrine; Fostemsavir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Enzalutamide induces CYP3A4, increasing temsavir clearance.

Conduite à tenir

Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if inducer exposure was recent.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Enzalutamide et Fostemsavir, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Enzalutamide with Fostemsavir?

MediHelp rates the interaction as contraindicated. Enzalutamide and Fostemsavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fostemsavir's active moiety temsavir is a CYP3A4 substrate, and strong inducers substantially lower its concentrations. Labeling contraindicates the combination because of loss of virologic response and resistance.

How serious is the interaction between Enzalutamide and Fostemsavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antiandrogen or antiretroviral. Monitor HIV RNA if inducer exposure was recent.

What other medicines interact with Enzalutamide?

MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter