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Interactions médicamenteuses

Fostemsavir + Pimozide

Gravité: Majeure

Fostemsavir and Pimozide: major interaction.

Dernière mise à jour

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Résumé

Fostemsavir has caused QT prolongation at supratherapeutic doses, and pimozide is a strongly QT-prolonging drug with a narrow margin of safety. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.

Ce que signifie cette interaction, en termes simples

Fostemsavir and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fostemsavir belongs to Anti Virals; Pimozide belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT-interval prolongation through cardiac repolarization effects.

Conduite à tenir

Obtain a baseline ECG and monitor QTc and electrolytes if the combination cannot be avoided. Correct potassium and magnesium abnormalities, and choose an alternative if QTc becomes markedly prolonged.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fostemsavir with Pimozide?

MediHelp rates the interaction as major. Fostemsavir and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fostemsavir has caused QT prolongation at supratherapeutic doses, and pimozide is a strongly QT-prolonging drug with a narrow margin of safety. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.

How serious is the interaction between Fostemsavir and Pimozide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes if the combination cannot be avoided. Correct potassium and magnesium abnormalities, and choose an alternative if QTc becomes markedly prolonged.

What other medicines interact with Pimozide?

MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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