Référentiel des médicaments
Givinostat
Givinostat is a medicine in the class miscellaneous. It is used for duchenne muscular dystrophy.
- Classe médicamenteuse: Miscellaneous
- Indications: Duchenne Muscular Dystrophy
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- M09AX14
- Formes courantes
- suspension buvable
- Dosages courants
- 8.86 mg/ml
- Interactions connues
- 104 (Majeure: 45 · Modérée: 36 · Mineure: 23)
- Noms commerciaux
- 1
- Pays et marchés
- 2
Indications
Mécanisme d'action
Givinostat is a histone deacetylase inhibitor. The precise mechanism by which it acts in DMD is unknown.
Grossesse et allaitement
- Grossesse
- Unsafe Used for Duchenne muscular dystrophy, which affects almost only boys, so there are no pregnancy data. In rats and rabbits it lowered fetal weight and raised fetal and pup deaths and behaviour changes, some below human exposure.
- Allaitement
- Unknown No human or animal data on milk. LactMed: highly protein-bound, so milk levels are likely very low; not a reason to stop breastfeeding, but use with caution and watch the infant for diarrhoea, vomiting, bruising or bleeding.
Effets indésirables signalés
- Diarrhea
- Abdominal pain
- Thrombocytopenia
- Nausea/vomiting
- Hypertriglyceridemia
- Pyrexia
Précautions particulières
- Dose-related thrombocytopenia and myelosuppression (anemia, neutropenia); monitor blood counts every 2 weeks for first 2 months, at month 3, then every 3 months.
- Increased triglycerides; monitor at 1 month, 3 months, 6 months, then every 6 months. Discontinue if they remain elevated despite diet and dose adjustment.
- Gastrointestinal disturbances (diarrhea, nausea/vomiting, abdominal pain); consider antiemetics or antidiarrheals and replace fluids and electrolytes.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (104)
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
- Chlorpromazine + Givinostat Major
- Citalopram + Givinostat Major
- Clomipramine + Givinostat Major
- Clozapine + Givinostat Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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Questions fréquentes
What is Givinostat used for?
Givinostat is a medicine in the class miscellaneous. It is used for Duchenne Muscular Dystrophy.
What side effects have been reported with Givinostat?
Diarrhea, Abdominal pain, Thrombocytopenia, Nausea/vomiting, Hypertriglyceridemia, Pyrexia.
Can Givinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Used for Duchenne muscular dystrophy, which affects almost only boys, so there are no pregnancy data. In rats and rabbits it lowered fetal weight and raised fetal and pup deaths and behaviour changes, some below human exposure. Breastfeeding: Unknown. No human or animal data on milk. LactMed: highly protein-bound, so milk levels are likely very low; not a reason to stop breastfeeding, but use with caution and watch the infant for diarrhoea, vomiting, bruising or bleeding.
What does Givinostat interact with?
MediHelp lists 104 known interactions for Givinostat. Major: 45 · Moderate: 36 · Minor: 23. The most serious include Abiraterone, Amiodarone, Amisulpride.
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