Interactions médicamenteuses
Amitriptyline + Givinostat
Gravité: Majeure
Amitriptyline and Givinostat: major interaction.
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Résumé
Both drugs can lengthen the QTc interval, increasing the potential for serious ventricular arrhythmias. The risk is higher with electrolyte abnormalities or cardiac disease.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Pourquoi elle survient
Additive QTc prolongation through effects on cardiac repolarization.
Conduite à tenir
Obtain ECGs at initiation and during concurrent use, and correct electrolyte abnormalities. Withhold the interacting drugs if QTc exceeds 500 ms or rises more than 60 ms from baseline.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Autres interactions de Givinostat
- Abiraterone + Givinostat Majeure
- Amiodarone + Givinostat Majeure
- Amisulpride + Givinostat Majeure
- Anagrelide + Givinostat Majeure
- Asenapine + Givinostat Majeure
- Chlorpromazine + Givinostat Majeure
Questions fréquentes
Can I take Amitriptyline with Givinostat?
MediHelp rates the interaction as major. Amitriptyline and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can lengthen the QTc interval, increasing the potential for serious ventricular arrhythmias. The risk is higher with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Amitriptyline and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during concurrent use, and correct electrolyte abnormalities. Withhold the interacting drugs if QTc exceeds 500 ms or rises more than 60 ms from baseline.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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