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Interactions médicamenteuses

Chlorpromazine + Givinostat

Gravité: Majeure

Chlorpromazine and Givinostat: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Both agents can lengthen the QTc interval, so concurrent use increases the likelihood of torsade de pointes. The risk is amplified by electrolyte abnormalities or cardiac disease.

Ce que signifie cette interaction, en termes simples

Chlorpromazine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Chlorpromazine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation through effects on cardiac repolarization.

Conduite à tenir

Avoid if possible. If coadministration is necessary, obtain ECGs at initiation and during use, and withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Chlorpromazine with Givinostat?

MediHelp rates the interaction as major. Chlorpromazine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QTc interval, so concurrent use increases the likelihood of torsade de pointes. The risk is amplified by electrolyte abnormalities or cardiac disease.

How serious is the interaction between Chlorpromazine and Givinostat?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministration is necessary, obtain ECGs at initiation and during use, and withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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