Référentiel des médicaments
Lasmiditan
Lasmiditan is a medicine in the class central nervous system. It is used for migraine.
- Classe médicamenteuse: Central Nervous System
- Indications: migraine
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Code ATC
- N02CC08
- Formes courantes
- comprimé
- Dosages courants
- 100 mg
- Interactions connues
- 220 (Modérée: 159 · Mineure: 61)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Binds with high affinity to the 5-HT1F receptor and presumably acts through agonist effects at this receptor; the precise mechanism is unknown.
Posologie adulte habituelle (résumé de la notice)
Acute treatment of migraine with or without aura: 50 mg, 100 mg, or 200 mg orally as needed; no more than one dose in 24 hours
Grossesse et allaitement
- Grossesse
- Unsafe No adequate human data. In animals it caused fetal abnormalities, fetal and pup deaths and lower fetal weight, in rabbits at exposures below human levels. EU label: not recommended in pregnancy. Prefer a better-studied migraine drug (e.g. sumatriptan); a pregnancy registry exists.
- Allaitement
- Unknown No human milk data; rat milk levels were about 3 times plasma. US label: weigh benefits. EU label: decide; avoiding breastfeeding for 24 hours after a dose minimises exposure. LactMed: not a reason to stop for an older infant, but another drug may be preferred for a newborn or preterm infant.
Effets indésirables signalés
- Dizziness
- Fatigue
- Paresthesia
- Sedation
- Nausea and/or vomiting
- Muscle weakness
Précautions particulières
- Driving impairment: do not drive or operate machinery for at least 8 hours after each dose; patients unable to comply should not take it.
- CNS depression, including dizziness and sedation; use caution with alcohol or other CNS depressants.
- Serotonin syndrome reported; discontinue if suspected.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (220)
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
- Atenolol + Lasmiditan Moderate
- Atenolol-chlorthalidone + Lasmiditan Moderate
- Atorvastatin + Lasmiditan Moderate
- Baclofen + Lasmiditan Moderate
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Questions fréquentes
What is Lasmiditan used for?
Lasmiditan is a medicine in the class central nervous system. It is used for Migraine.
What side effects have been reported with Lasmiditan?
Dizziness, Fatigue, Paresthesia, Sedation, Nausea and/or vomiting, Muscle weakness.
Can Lasmiditan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No adequate human data. In animals it caused fetal abnormalities, fetal and pup deaths and lower fetal weight, in rabbits at exposures below human levels. EU label: not recommended in pregnancy. Prefer a better-studied migraine drug (e.g. sumatriptan); a pregnancy registry exists. Breastfeeding: Unknown. No human milk data; rat milk levels were about 3 times plasma. US label: weigh benefits. EU label: decide; avoiding breastfeeding for 24 hours after a dose minimises exposure. LactMed: not a reason to stop for an older infant, but another drug may be preferred for a newborn or preterm infant.
What does Lasmiditan interact with?
MediHelp lists 220 known interactions for Lasmiditan. Moderate: 159 · Minor: 61. The most serious include Alprazolam, Amiodarone, Amisulpride.
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