Référentiel des médicaments
Lesinurad
Lesinurad is a medicine in the class genitourinary.
- Classe médicamenteuse: Genitourinary
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Genitourinary
- Interactions connues
- 58 (Majeure: 1 · Modérée: 23 · Mineure: 34)
- Noms commerciaux
- 1
Mécanisme d'action
Selective uric acid reabsorption inhibitor (SURI); it acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia
Posologie adulte habituelle (résumé de la notice)
Hyperuricemia: 200 mg PO qDay in combination with a xanthine oxidase inhibitor (ie, allopurinol or febuxostat)
Grossesse et allaitement
- Grossesse
- Unknown Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait.
- Allaitement
- Unknown Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
Effets indésirables signalés
- Headache
- Influenza
- Renal failure
- GERD
- Increased creatinine
Contre-indications
- Severe renal impairment (estimated CrCl <30 mL/min), end-stage renal disease, kidney transplant recipients, or patients on dialysis
- Tumor lysis syndrome or Lesch-Nyhan syndrome
Précautions particulières
- Contraindicated in Tumor lysis syndrome or Lesch-Nyhan syndrome.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (58)
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
- Ethinyl estradiol-drospirenone + Lesinurad Moderate
- Ethinyl estradiol-levonorgestrel + Lesinurad Moderate
- Ethinylestradiol + Lesinurad Moderate
- Etonogestrel + Lesinurad Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Lesinurad used for?
Lesinurad is a medicine in the class genitourinary.
What side effects have been reported with Lesinurad?
Headache, Influenza, Renal failure, GERD, Increased creatinine.
Can Lesinurad be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait. Breastfeeding: Unknown. Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
What does Lesinurad interact with?
MediHelp lists 58 known interactions for Lesinurad. Major: 1 · Moderate: 23 · Minor: 34. The most serious include Norethisterone, Acetylsalicylic acid, Amiodarone.
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