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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Ethinyl estradiol-drospirenone + Lesinurad

Gravité: Modérée

Ethinyl estradiol-drospirenone and Lesinurad: moderate interaction.

Dernière mise à jour

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Résumé

Lesinurad is a weak inducer of CYP3A and may lower exposure to hormonal contraceptive components. This can reduce contraceptive efficacy and risk unintended pregnancy.

Ce que signifie cette interaction, en termes simples

Ethinyl estradiol-drospirenone and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Ethinyl estradiol-drospirenone belongs to Endocrine; Lesinurad belongs to Genitourinary.

Niveau de preuve: Moderate

Pourquoi elle survient

Weak induction of CYP3A4 by lesinurad increases metabolic clearance of ethinyl estradiol and progestins.

Conduite à tenir

Advise an additional non-hormonal contraceptive method while taking lesinurad. Do not rely on hormonal contraception alone.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ethinyl estradiol-drospirenone with Lesinurad?

MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad is a weak inducer of CYP3A and may lower exposure to hormonal contraceptive components. This can reduce contraceptive efficacy and risk unintended pregnancy.

How serious is the interaction between Ethinyl estradiol-drospirenone and Lesinurad?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method while taking lesinurad. Do not rely on hormonal contraception alone.

What other medicines interact with Ethinyl estradiol-drospirenone?

MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.

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