Référentiel des médicaments
Oliceridine
Oliceridine is a medicine in the class musculoskeletal. It is used for pain management.
- Classe médicamenteuse: Musculoskeletal
- Indications: pain management
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Musculoskeletal
- Formes courantes
- injection
- Interactions connues
- 200 (Contre-indiquée: 1 · Majeure: 98 · Modérée: 78 · Mineure: 23)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Oliceridine is a full opioid agonist, relatively selective for the mu-opioid receptor; its principal therapeutic action is analgesia, with no ceiling effect to analgesia.
Posologie adulte habituelle (résumé de la notice)
Acute pain severe enough to require an IV opioid: initial dose 1.5 mg IV given by a healthcare provider; supplemental doses of 0.75 mg beginning 1 hour after the initial dose and hourly thereafter as needed; single doses greater than 3 mg not to be given; maximum cumulative daily dose 27 mg.
Grossesse et allaitement
- Grossesse
- Unsafe Prolonged use in pregnancy may cause neonatal opioid withdrawal syndrome; no human data on birth defects. Animal studies showed reduced live litter size and increased pup mortality. Not recommended during and immediately before labor.
- Allaitement
- Unknown It is not known whether oliceridine is in human milk; weigh the benefits of breastfeeding against the mother's need. Monitor exposed infants for excess sedation and respiratory depression.
Effets indésirables signalés
- Nausea
- Vomiting
- Dizziness
- Headache
- Constipation
- Pruritus
Mises en garde encadrées
- Exposes users to risks of opioid addiction, abuse and misuse, which can lead to overdose and death; assess risk before prescribing and reassess regularly. Serious, life-threatening or fatal respiratory depression may occur, especially during initiation or after a dosage increase. Concomitant use with benzodiazepines or other CNS depressants, including alcohol, may cause profound sedation, respiratory depression, coma and death; reserve for patients with inadequate alternatives. Prolonged use in pregnancy can cause neonatal opioid withdrawal syndrome, which may be life-threatening.
Contre-indications
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or without resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
Précautions particulières
- QTc prolongation risk with cumulative daily doses above 27 mg; do not exceed 27 mg.
- Increased oliceridine exposure with decreased CYP2D6 function or with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can prolong adverse reactions and worsen respiratory depression.
- Opioid-induced hyperalgesia and allodynia may occur; consider dose reduction or opioid rotation if suspected.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (200)
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
- Aripiprazole + Oliceridine Major
- Asenapine + Oliceridine Major
- Baclofen + Oliceridine Major
- Brexpiprazole + Oliceridine Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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- Patient counselling points
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Questions fréquentes
What is Oliceridine used for?
Oliceridine is a medicine in the class musculoskeletal. It is used for Pain management.
What side effects have been reported with Oliceridine?
Nausea, Vomiting, Dizziness, Headache, Constipation, Pruritus. Serious warning: Exposes users to risks of opioid addiction, abuse and misuse, which can lead to overdose and death; assess risk before prescribing and reassess regularly.
Can Oliceridine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Prolonged use in pregnancy may cause neonatal opioid withdrawal syndrome; no human data on birth defects. Animal studies showed reduced live litter size and increased pup mortality. Not recommended during and immediately before labor. Breastfeeding: Unknown. It is not known whether oliceridine is in human milk; weigh the benefits of breastfeeding against the mother's need. Monitor exposed infants for excess sedation and respiratory depression.
What does Oliceridine interact with?
MediHelp lists 200 known interactions for Oliceridine. Contraindicated: 1 · Major: 98 · Moderate: 78 · Minor: 23. The most serious include Isocarboxazid, Alprazolam, Amiodarone.
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