Interactions médicamenteuses
Aripiprazole + Oliceridine
Gravité: Majeure
Aripiprazole and Oliceridine: major interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Oliceridine is an opioid that causes sedation and respiratory depression, and aripiprazole adds CNS depressant effects. Oliceridine is also partly metabolized by CYP3A4 and CYP2D6, which aripiprazole does not substantially affect, so the main concern is additive depression.
Ce que signifie cette interaction, en termes simples
Aripiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Pourquoi elle survient
Additive CNS and respiratory depression between an opioid and an antipsychotic.
Conduite à tenir
Reserve combined use for patients without adequate alternatives, using the lowest oliceridine dose for the shortest duration. Monitor sedation and respiratory rate closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: other CNS medicinal products with overlapping adverse reactions such as sedation; "caution should be used when aripiprazole is administered in combination with alcohol or other CNS medicinal products with overlapping adverse re… — electronic medicines compendium (UK SmPC)
Autres interactions de Aripiprazole
- Aripiprazole + Pimozide Contre-indiquée
- Aripiprazole + Thioridazine Contre-indiquée
- Amisulpride + Aripiprazole Majeure
- Aripiprazole + Arsenic trioxide Majeure
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Majeure
- Aripiprazole + Carbamazepine Majeure
Autres interactions de Oliceridine
- Isocarboxazid + Oliceridine Contre-indiquée
- Alprazolam + Oliceridine Majeure
- Amiodarone + Oliceridine Majeure
- Amisulpride + Oliceridine Majeure
- Amitriptyline + Oliceridine Majeure
- Amobarbital + Oliceridine Majeure
Questions fréquentes
Can I take Aripiprazole with Oliceridine?
MediHelp rates the interaction as major. Aripiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an opioid that causes sedation and respiratory depression, and aripiprazole adds CNS depressant effects. Oliceridine is also partly metabolized by CYP3A4 and CYP2D6, which aripiprazole does not substantially affect, so the main concern is additive depression.
How serious is the interaction between Aripiprazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives, using the lowest oliceridine dose for the shortest duration. Monitor sedation and respiratory rate closely.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
