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Interactions médicamenteuses

Alprazolam + Oliceridine

Gravité: Majeure

Alprazolam and Oliceridine: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Combining an opioid with a benzodiazepine produces additive central nervous system and respiratory depression. Profound sedation, respiratory failure, coma and death can result.

Ce que signifie cette interaction, en termes simples

Alprazolam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Alprazolam belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic CNS and respiratory depression via opioid and GABA-A receptor effects.

Conduite à tenir

Reserve combined use for patients without adequate alternatives, using the lowest effective doses and shortest duration. Monitor closely for sedation and respiratory depression.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Alprazolam with Oliceridine?

MediHelp rates the interaction as major. Alprazolam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine produces additive central nervous system and respiratory depression. Profound sedation, respiratory failure, coma and death can result.

How serious is the interaction between Alprazolam and Oliceridine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives, using the lowest effective doses and shortest duration. Monitor closely for sedation and respiratory depression.

What other medicines interact with Alprazolam?

MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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