Référentiel des médicaments
Selpercatinib
Selpercatinib is a medicine in the class oncology. It is used for cancer.
- Classe médicamenteuse: Oncology
- Indications: cancer
Dernière mise à jour Sources: EMA SmPC
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L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01EX22
- Formes courantes
- comprimé, gélule
- Dosages courants
- 40 mg
- Interactions connues
- 123 (Majeure: 72 · Modérée: 51)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Selpercatinib is an inhibitor of the RET receptor tyrosine kinase. It also inhibited VEGFR1 and VEGFR3 and, at higher concentrations, FGFR 1, 2 and 3.
Posologie adulte habituelle (résumé de la notice)
RET fusion-positive/RET-mutant tumours (patients 12 years and older, under 50 kg): 120 mg orally twice daily until disease progression or unacceptable toxicity
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm: in rats it caused embryo death and malformations at about human exposure. No human data. EU label: not recommended in pregnancy or without contraception. Check pregnancy status; use highly effective contraception during and for at least 1 week after.
- Allaitement
- Unsafe No human milk data. LactMed: 97% protein bound, so milk levels are likely low. Because of possible serious infant reactions, US and EU labels say do not breastfeed during treatment and for 1 week after the last dose.
Effets indésirables signalés
- Hypertension
- Increased AST
- Increased ALT
- Diarrhoea
- Fatigue
- Oedema
Contre-indications
- Hypersensitivity to the active substance or to any excipient.
Précautions particulières
- Severe, life-threatening or fatal ILD/pneumonitis; withhold, investigate and adjust or discontinue.
- Increased ALT/AST: monitor before treatment, every 2 weeks for 3 months, then monthly for 3 months.
- Hypertension: control blood pressure before starting and monitor; discontinue permanently if it cannot be controlled.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (123)
- Amiodarone + Selpercatinib Major
- Amisulpride + Selpercatinib Major
- Amitriptyline + Selpercatinib Major
- Amobarbital + Selpercatinib Major
- Anagrelide + Selpercatinib Major
- Apalutamide + Selpercatinib Major
- Asenapine + Selpercatinib Major
- Buprenorphine + Selpercatinib Major
- Carbamazepine + Selpercatinib Major
- Chloroquine + Selpercatinib Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Selpercatinib used for?
Selpercatinib is a medicine in the class oncology. It is used for Cancer, Non-small cell lung cancer, Thyroid cancer.
What side effects have been reported with Selpercatinib?
Hypertension, Increased AST, Increased ALT, Diarrhoea, Fatigue, Oedema.
Can Selpercatinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats it caused embryo death and malformations at about human exposure. No human data. EU label: not recommended in pregnancy or without contraception. Check pregnancy status; use highly effective contraception during and for at least 1 week after. Breastfeeding: Unsafe. No human milk data. LactMed: 97% protein bound, so milk levels are likely low. Because of possible serious infant reactions, US and EU labels say do not breastfeed during treatment and for 1 week after the last dose.
What does Selpercatinib interact with?
MediHelp lists 123 known interactions for Selpercatinib. Major: 72 · Moderate: 51. The most serious include Amiodarone, Amisulpride, Amitriptyline.
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