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Interactions médicamenteuses

Amiodarone + Selpercatinib

Gravité: Majeure

Amiodarone and Selpercatinib: major interaction.

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Résumé

Both drugs can prolong the QT interval, so giving them together may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or structural heart disease.

Ce que signifie cette interaction, en termes simples

Amiodarone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Selpercatinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic QT prolongation through cardiac repolarization effects.

Conduite à tenir

Obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium before and during treatment. Consider an alternative antiarrhythmic, or reduce or interrupt selpercatinib if QTc becomes markedly prolonged.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Selpercatinib?

MediHelp rates the interaction as major. Amiodarone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or structural heart disease.

How serious is the interaction between Amiodarone and Selpercatinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium before and during treatment. Consider an alternative antiarrhythmic, or reduce or interrupt selpercatinib if QTc becomes markedly prolonged.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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