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Interactions médicamenteuses

Amitriptyline + Selpercatinib

Gravité: Majeure

Amitriptyline and Selpercatinib: major interaction.

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Résumé

Both drugs can prolong the QT interval, so combining them may increase the risk of ventricular arrhythmias including Torsades de Pointes. The risk is greater with electrolyte disturbances or underlying heart disease.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amitriptyline belongs to Central Nervous System; Selpercatinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QTc prolongation through pharmacodynamic effects on cardiac repolarization.

Conduite à tenir

Monitor ECG and electrolytes at baseline and periodically, correcting potassium and magnesium abnormalities. Choose an alternative antidepressant if QTc rises significantly.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Selpercatinib?

MediHelp rates the interaction as major. Amitriptyline and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them may increase the risk of ventricular arrhythmias including Torsades de Pointes. The risk is greater with electrolyte disturbances or underlying heart disease.

How serious is the interaction between Amitriptyline and Selpercatinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting potassium and magnesium abnormalities. Choose an alternative antidepressant if QTc rises significantly.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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