Référentiel des médicaments
Vecuronium
Vecuronium is a medicine in the class musculoskeletal. It is used for general anesthesia.
- Classe médicamenteuse: Musculoskeletal
- Indications: general anesthesia
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Musculoskeletal
- Formes courantes
- injection
- Dosages courants
- 4 mg/ml
- Interactions connues
- 135 (Majeure: 14 · Modérée: 62 · Mineure: 59)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Non-depolarizing skeletal muscle relaxant; cholinergic receptor antagonist
Posologie adulte habituelle (résumé de la notice)
General Anesthesia (Injection) Load: 0.08-0.1 mg/kg IVP over 60 sec OR 0.04-0.06 mg/kg IVP if following succinylcholine, PLUS Maintenance: 0.01-0.015 mg/kg IVP 20-45min post initial PRN
Grossesse et allaitement
- Grossesse
- Safe Used during general anaesthesia, including caesarean section; it crosses the placenta only in small amounts. No animal reproduction studies. US label: use only if clearly needed. Magnesium sulphate can prolong its effect. Acceptable for anaesthesia when needed.
- Allaitement
- Safe No milk data, but it is short acting, highly polar and poorly absorbed by mouth, so little reaches milk or the infant (LactMed). Breastfeed once the mother has recovered; with several anaesthetic drugs, follow the most restrictive one.
Effets indésirables signalés
- Skeletal muscle weakness or paralysis
- Itching
- Respiratory insufficiency or apnea
Contre-indications
- Hypersensitivity
- Lack of ventilatory support
- Neuromuscular disease
Précautions particulières
- Some patients may experience prolonged recovery (paralysis) of neuromuscular function
- CAUTION: Hepatobiliary obstruction, renal dysfunction will significantly prolong duration of action
- Severe anaphylactic reactions to neuromuscular blocking agents have been reported; these reactions have, in some cases, been life threatening and fatal;
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (135)
- Amikacin + Vecuronium Major
- Bacitracin-neomycin-polymyxin + Vecuronium Major
- Capreomycin + Vecuronium Major
- Clindamycin + Vecuronium Major
- Colistin + Vecuronium Major
- Dexamethasone-tobramycin + Vecuronium Major
- Gentamicin + Vecuronium Major
- Lincomycin + Vecuronium Major
- Magnesium + Vecuronium Major
- Magnesium sulfate + Vecuronium Major
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Vecuronium used for?
Vecuronium is a medicine in the class musculoskeletal. It is used for General anesthesia.
What side effects have been reported with Vecuronium?
Skeletal muscle weakness or paralysis, Itching, Respiratory insufficiency or apnea.
Can Vecuronium be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Used during general anaesthesia, including caesarean section; it crosses the placenta only in small amounts. No animal reproduction studies. US label: use only if clearly needed. Magnesium sulphate can prolong its effect. Acceptable for anaesthesia when needed. Breastfeeding: Safe. No milk data, but it is short acting, highly polar and poorly absorbed by mouth, so little reaches milk or the infant (LactMed). Breastfeed once the mother has recovered; with several anaesthetic drugs, follow the most restrictive one.
What does Vecuronium interact with?
MediHelp lists 135 known interactions for Vecuronium. Major: 14 · Moderate: 62 · Minor: 59. The most serious include Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
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