Interactions médicamenteuses
Gentamicin + Vecuronium
Gravité: Majeure
Gentamicin and Vecuronium: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Aminoglycosides such as gentamicin have intrinsic neuromuscular blocking activity and can deepen and prolong the paralysis produced by vecuronium. This may delay recovery of spontaneous breathing and cause postoperative residual paralysis or recurrent respiratory depression.
Ce que signifie cette interaction, en termes simples
Gentamicin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
Pourquoi elle survient
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade by the aminoglycoside.
Conduite à tenir
Use quantitative neuromuscular monitoring and reduce vecuronium dosing when gentamicin is given perioperatively. Keep ventilatory support available until full recovery is confirmed, and consider a non-aminoglycoside antibiotic if suitable.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Gentamicin et Vecuronium, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Vecuronium
- Amikacin + Vecuronium Majeure
- Bacitracin-neomycin-polymyxin + Vecuronium Majeure
- Capreomycin + Vecuronium Majeure
- Clindamycin + Vecuronium Majeure
- Colistin + Vecuronium Majeure
- Dexamethasone-tobramycin + Vecuronium Majeure
Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
Questions fréquentes
Can I take Gentamicin with Vecuronium?
MediHelp rates the interaction as major. Gentamicin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides such as gentamicin have intrinsic neuromuscular blocking activity and can deepen and prolong the paralysis produced by vecuronium. This may delay recovery of spontaneous breathing and cause postoperative residual paralysis or recurrent respiratory depression.
How serious is the interaction between Gentamicin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use quantitative neuromuscular monitoring and reduce vecuronium dosing when gentamicin is given perioperatively. Keep ventilatory support available until full recovery is confirmed, and consider a non-aminoglycoside antibiotic if suitable.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
