Interactions médicamenteuses
Bacitracin-neomycin-polymyxin + Vecuronium
Gravité: Majeure
Bacitracin-neomycin-polymyxin and Vecuronium: major interaction.
Dernière mise à jour
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Résumé
Polymyxin B and neomycin can potentiate vecuronium's neuromuscular blockade. This may prolong paralysis and delay recovery of spontaneous breathing. The risk is mainly with systemic or irrigation use, not small topical areas.
Ce que signifie cette interaction, en termes simples
Bacitracin-neomycin-polymyxin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
Pourquoi elle survient
Additive pharmacodynamic neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor effects.
Conduite à tenir
Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Majeure
- Atracurium + Bacitracin-neomycin-polymyxin Majeure
- Bacitracin-neomycin-polymyxin + Capreomycin Majeure
- Bacitracin-neomycin-polymyxin + Cidofovir Majeure
- Bacitracin-neomycin-polymyxin + Cisatracurium Majeure
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
Autres interactions de Vecuronium
- Amikacin + Vecuronium Majeure
- Capreomycin + Vecuronium Majeure
- Clindamycin + Vecuronium Majeure
- Colistin + Vecuronium Majeure
- Dexamethasone-tobramycin + Vecuronium Majeure
- Gentamicin + Vecuronium Majeure
Questions fréquentes
Can I take Bacitracin-neomycin-polymyxin with Vecuronium?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B and neomycin can potentiate vecuronium's neuromuscular blockade. This may prolong paralysis and delay recovery of spontaneous breathing. The risk is mainly with systemic or irrigation use, not small topical areas.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
