Référentiel des médicaments
Venetoclax
Venetoclax is a medicine in the class miscellaneous. It is used for chronic lymphocytic leukemia.
- Classe médicamenteuse: Miscellaneous
- Indications: chronic lymphocytic leukemia
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- L01XX52
- Formes courantes
- comprimé
- Dosages courants
- 10 mg
- Interactions connues
- 68 (Contre-indiquée: 5 · Majeure: 37 · Modérée: 23 · Mineure: 3)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Selective, orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. It binds BCL-2 directly, displacing pro-apoptotic proteins like BIM, which restores apoptosis through mitochondrial outer membrane permeabilization and caspase activation.
Posologie adulte habituelle (résumé de la notice)
CLL/SLL: 5-week ramp-up orally once daily (Week 1 20 mg, Week 2 50 mg, Week 3 100 mg, Week 4 200 mg), then 400 mg once daily from Week 5 and beyond
Grossesse et allaitement
- Grossesse
- Unsafe May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose.
- Allaitement
- Unsafe No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
Effets indésirables signalés
- Neutropenia
- Thrombocytopenia
- Anemia
- Diarrhea
- Nausea
- Fatigue
Contre-indications
- Concomitant use with strong CYP3A inhibitors at initiation and during the ramp-up phase in patients with CLL/SLL, due to increased TLS risk
Précautions particulières
- Tumor lysis syndrome, including fatal events and renal failure requiring dialysis; assess risk, give hydration and anti-hyperuricemics, and monitor blood chemistries
- Neutropenia: monitor complete blood counts throughout treatment and consider supportive measures
- Fatal and serious infections such as pneumonia and sepsis; withhold for Grade 3 and 4 infection until resolution
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (68)
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
- Apalutamide + Venetoclax Major
- Aprepitant + Venetoclax Major
- Armodafinil + Venetoclax Major
- Bosentan + Venetoclax Major
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- Renal and hepatic dose adjustments
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Questions fréquentes
What is Venetoclax used for?
Venetoclax is a medicine in the class miscellaneous. It is used for Chronic lymphocytic leukemia, Leukemia.
What side effects have been reported with Venetoclax?
Neutropenia, Thrombocytopenia, Anemia, Diarrhea, Nausea, Fatigue.
Can Venetoclax be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose. Breastfeeding: Unsafe. No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
What does Venetoclax interact with?
MediHelp lists 68 known interactions for Venetoclax. Contraindicated: 5 · Major: 37 · Moderate: 23 · Minor: 3. The most serious include Clarithromycin, Itraconazole, Ketoconazole.
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