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Interactions médicamenteuses

Amiodarone + Venetoclax

Gravité: Majeure

Amiodarone and Venetoclax: major interaction.

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Résumé

Amiodarone may increase venetoclax exposure, raising the risk of neutropenia and, in patients with high tumor burden, tumor lysis syndrome. Both CYP3A and P-gp inhibition contribute to this effect.

Ce que signifie cette interaction, en termes simples

Amiodarone and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Amiodarone inhibits CYP3A4 and P-gp, decreasing venetoclax metabolism and efflux.

Conduite à tenir

Avoid if possible; otherwise reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the prior dose after the inhibitor has been cleared, noting the long amiodarone half-life.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Venetoclax?

MediHelp rates the interaction as major. Amiodarone and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may increase venetoclax exposure, raising the risk of neutropenia and, in patients with high tumor burden, tumor lysis syndrome. Both CYP3A and P-gp inhibition contribute to this effect.

How serious is the interaction between Amiodarone and Venetoclax?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the prior dose after the inhibitor has been cleared, noting the long amiodarone half-life.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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