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Interactions médicamenteuses

Venetoclax + Voriconazole

Gravité: Contre-indiquée

Venetoclax and Voriconazole: contraindicated interaction.

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Résumé

Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.

Ce que signifie cette interaction, en termes simples

Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Venetoclax belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.

Niveau de preuve: High

Pourquoi elle survient

Strong CYP3A4 inhibition (and possible P-gp inhibition) reduces venetoclax clearance.

Conduite à tenir

Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Venetoclax with Voriconazole?

MediHelp rates the interaction as contraindicated. Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.

How serious is the interaction between Venetoclax and Voriconazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.

What other medicines interact with Voriconazole?

MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.

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