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Interactions médicamenteuses

Abacavir + Ribavirin

Gravité: Modérée

Abacavir and Ribavirin: moderate interaction.

Dernière mise à jour

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Résumé

Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.

Ce que signifie cette interaction, en termes simples

Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Abacavir belongs to Anti Virals; Ribavirin belongs to Anti Virals.

Niveau de preuve: Low

Pourquoi elle survient

Possible additive mitochondrial toxicity; ribavirin may also alter intracellular nucleoside phosphorylation, though this is not firmly established for abacavir.

Conduite à tenir

Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Abacavir with Ribavirin?

MediHelp rates the interaction as moderate. Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.

How serious is the interaction between Abacavir and Ribavirin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.

What other medicines interact with Ribavirin?

MediHelp also lists interactions of Ribavirin with, for example, Didanosine, Stavudine, Zidovudine. The full list is on the Ribavirin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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