Interactions médicamenteuses
Abrocitinib + Ticagrelor
Gravité: Majeure
Abrocitinib and Ticagrelor: major interaction.
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Résumé
Abrocitinib reduces platelet counts, mainly in the early weeks of treatment, and its labeling advises against antiplatelet drugs other than low-dose aspirin during the first 3 months. Adding ticagrelor, a potent P2Y12 inhibitor, to thrombocytopenia increases the risk of significant bleeding.
Ce que signifie cette interaction, en termes simples
Abrocitinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abrocitinib belongs to Miscellaneous; Ticagrelor belongs to Cardiovascular.
Pourquoi elle survient
Additive bleeding risk from ticagrelor platelet inhibition combined with abrocitinib-associated reduction in platelet count.
Conduite à tenir
Avoid starting abrocitinib in patients who need ticagrelor during the first 3 months, or choose an alternative therapy. If unavoidable, monitor platelet counts and bleeding signs closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ticagrelor
- Itraconazole + Ticagrelor Contre-indiquée
- Ketoconazole + Ticagrelor Contre-indiquée
- Levoketoconazole + Ticagrelor Contre-indiquée
- Abciximab + Ticagrelor Majeure
- Acalabrutinib + Ticagrelor Majeure
- Acetylsalicylic acid + Ticagrelor Majeure
Autres interactions de Abrocitinib
- Abrocitinib + Upadacitinib Contre-indiquée
- Abciximab + Abrocitinib Majeure
- Abrocitinib + Anagrelide Majeure
- Abrocitinib + Cilostazol Majeure
- Abrocitinib + Clopidogrel Majeure
- Abrocitinib + Eptifibatide Majeure
Questions fréquentes
Can I take Abrocitinib with Ticagrelor?
MediHelp rates the interaction as major. Abrocitinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Abrocitinib reduces platelet counts, mainly in the early weeks of treatment, and its labeling advises against antiplatelet drugs other than low-dose aspirin during the first 3 months. Adding ticagrelor, a potent P2Y12 inhibitor, to thrombocytopenia increases the risk of significant bleeding.
How serious is the interaction between Abrocitinib and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting abrocitinib in patients who need ticagrelor during the first 3 months, or choose an alternative therapy. If unavoidable, monitor platelet counts and bleeding signs closely.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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