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Interactions médicamenteuses

Acalabrutinib + Ticagrelor

Gravité: Majeure

Acalabrutinib and Ticagrelor: major interaction.

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Résumé

Acalabrutinib impairs platelet function and is associated with bleeding and hemorrhage. Adding ticagrelor, a potent P2Y12 inhibitor, further raises bleeding risk including serious events.

Ce que signifie cette interaction, en termes simples

Acalabrutinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Acalabrutinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive platelet inhibition from BTK inhibition and P2Y12 receptor blockade.

Conduite à tenir

Monitor for bleeding and weigh the necessity of combined therapy. Consider holding acalabrutinib around surgery as per labeling.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Acalabrutinib with Ticagrelor?

MediHelp rates the interaction as major. Acalabrutinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib impairs platelet function and is associated with bleeding and hemorrhage. Adding ticagrelor, a potent P2Y12 inhibitor, further raises bleeding risk including serious events.

How serious is the interaction between Acalabrutinib and Ticagrelor?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and weigh the necessity of combined therapy. Consider holding acalabrutinib around surgery as per labeling.

What other medicines interact with Ticagrelor?

MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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