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Interactions médicamenteuses

Levoketoconazole + Ticagrelor

Gravité: Contre-indiquée

Levoketoconazole and Ticagrelor: contraindicated interaction.

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Résumé

Levoketoconazole is a strong CYP3A inhibitor and is expected to markedly increase ticagrelor exposure, raising bleeding risk. Strong CYP3A inhibitors such as ketoconazole are not recommended with ticagrelor.

Ce que signifie cette interaction, en termes simples

Levoketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Levoketoconazole belongs to Endocrine; Ticagrelor belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Strong CYP3A4 inhibition reduces ticagrelor clearance.

Conduite à tenir

Avoid the combination and choose an alternative antiplatelet. If antifungal or cortisol-lowering therapy is needed, consider an option without strong CYP3A inhibition.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Levoketoconazole with Ticagrelor?

MediHelp rates the interaction as contraindicated. Levoketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A inhibitor and is expected to markedly increase ticagrelor exposure, raising bleeding risk. Strong CYP3A inhibitors such as ketoconazole are not recommended with ticagrelor.

How serious is the interaction between Levoketoconazole and Ticagrelor?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiplatelet. If antifungal or cortisol-lowering therapy is needed, consider an option without strong CYP3A inhibition.

What other medicines interact with Ticagrelor?

MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Abciximab. The full list is on the Ticagrelor page.

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