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Interactions médicamenteuses

Acalabrutinib + Lansoprazole

Gravité: Majeure

Acalabrutinib and Lansoprazole: major interaction.

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Résumé

Acalabrutinib capsules need an acidic stomach to dissolve, and lansoprazole raises gastric pH for a prolonged period. This can substantially lower acalabrutinib absorption and may reduce its anticancer efficacy.

Ce que signifie cette interaction, en termes simples

Acalabrutinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Acalabrutinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.

Niveau de preuve: High

Pourquoi elle survient

PPI-induced rise in gastric pH reduces the solubility and absorption of acalabrutinib capsules.

Conduite à tenir

Avoid the PPI where possible; an antacid taken 2 hours apart or an H2 blocker taken 2 hours after acalabrutinib is an alternative. The tablet formulation, which is not pH dependent, can be used if a PPI is required.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Acalabrutinib with Lansoprazole?

MediHelp rates the interaction as major. Acalabrutinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib capsules need an acidic stomach to dissolve, and lansoprazole raises gastric pH for a prolonged period. This can substantially lower acalabrutinib absorption and may reduce its anticancer efficacy.

How serious is the interaction between Acalabrutinib and Lansoprazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI where possible; an antacid taken 2 hours apart or an H2 blocker taken 2 hours after acalabrutinib is an alternative. The tablet formulation, which is not pH dependent, can be used if a PPI is required.

What other medicines interact with Lansoprazole?

MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Lansoprazole page.

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