Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Dasatinib + Lansoprazole

Gravité: Majeure

Dasatinib and Lansoprazole: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Dasatinib solubility is pH-dependent, and PPIs significantly reduce its absorption and exposure, which may compromise treatment of leukemia.

Ce que signifie cette interaction, en termes simples

Dasatinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dasatinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.

Niveau de preuve: High

Pourquoi elle survient

Raised gastric pH reduces dissolution and absorption of dasatinib.

Conduite à tenir

Avoid PPIs with dasatinib. Use a short-acting antacid given at least 2 hours before or after dasatinib, or an H2 blocker timed carefully, if acid suppression is needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Dasatinib et Lansoprazole, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Dasatinib with Lansoprazole?

MediHelp rates the interaction as major. Dasatinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib solubility is pH-dependent, and PPIs significantly reduce its absorption and exposure, which may compromise treatment of leukemia.

How serious is the interaction between Dasatinib and Lansoprazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. Use a short-acting antacid given at least 2 hours before or after dasatinib, or an H2 blocker timed carefully, if acid suppression is needed.

What other medicines interact with Lansoprazole?

MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter