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Interactions médicamenteuses

Lansoprazole + Rilpivirine

Gravité: Contre-indiquée

Lansoprazole and Rilpivirine: contraindicated interaction.

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Résumé

Lansoprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.

Ce que signifie cette interaction, en termes simples

Lansoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lansoprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Elevated gastric pH reduces absorption of oral rilpivirine, which needs an acidic environment.

Conduite à tenir

Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lansoprazole with Rilpivirine?

MediHelp rates the interaction as contraindicated. Lansoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lansoprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.

How serious is the interaction between Lansoprazole and Rilpivirine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).

What other medicines interact with Lansoprazole?

MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Acalabrutinib, Atazanavir. The full list is on the Lansoprazole page.

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