Interactions médicamenteuses
Acebutolol + Clonidine
Gravité: Majeure
Acebutolol and Clonidine: major interaction.
Dernière mise à jour
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Résumé
Beta blockers can worsen rebound hypertension when clonidine is stopped or doses are missed, because unopposed alpha stimulation occurs during catecholamine surge. Both drugs also lower heart rate, so bradycardia may be additive during concurrent use.
Ce que signifie cette interaction, en termes simples
Acebutolol and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Beta blockade leaves alpha-mediated vasoconstriction unopposed during clonidine withdrawal, and both drugs reduce heart rate and sympathetic tone.
Conduite à tenir
If clonidine must be stopped, withdraw the beta blocker first and taper clonidine gradually over several days. Monitor blood pressure and heart rate throughout.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Clonidine
- Amifostine + Clonidine Majeure
- Amiodarone + Clonidine Majeure
- Amoxapine + Clonidine Majeure
- Atenolol-chlorthalidone + Clonidine Majeure
- Atenolol + Clonidine Majeure
- Betaxolol + Clonidine Majeure
Questions fréquentes
Can I take Acebutolol with Clonidine?
MediHelp rates the interaction as major. Acebutolol and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Beta blockers can worsen rebound hypertension when clonidine is stopped or doses are missed, because unopposed alpha stimulation occurs during catecholamine surge. Both drugs also lower heart rate, so bradycardia may be additive during concurrent use.
How serious is the interaction between Acebutolol and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If clonidine must be stopped, withdraw the beta blocker first and taper clonidine gradually over several days. Monitor blood pressure and heart rate throughout.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Amifostine, Amiodarone, Amoxapine. The full list is on the Clonidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
