Interactions médicamenteuses
Atenolol-chlorthalidone + Clonidine
Gravité: Majeure
Atenolol-chlorthalidone and Clonidine: major interaction.
Dernière mise à jour
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Résumé
Clonidine lowers heart rate and blood pressure, and atenolol adds to this effect. Importantly, if clonidine is withdrawn while on a beta-blocker, severe rebound hypertension can occur.
Ce que signifie cette interaction, en termes simples
Atenolol-chlorthalidone and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Clonidine belongs to Cardiovascular.
Pourquoi elle survient
Additive bradycardic and hypotensive effects; beta-blockade leaves unopposed alpha-mediated vasoconstriction during clonidine withdrawal rebound.
Conduite à tenir
If both are used, monitor heart rate and blood pressure. To stop therapy, withdraw the beta-blocker gradually first, then taper clonidine several days later.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Atenolol-chlorthalidone
Autres interactions de Clonidine
- Acebutolol + Clonidine Majeure
- Amifostine + Clonidine Majeure
- Amiodarone + Clonidine Majeure
- Amoxapine + Clonidine Majeure
- Atenolol + Clonidine Majeure
- Betaxolol + Clonidine Majeure
Questions fréquentes
Can I take Atenolol-chlorthalidone with Clonidine?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clonidine lowers heart rate and blood pressure, and atenolol adds to this effect. Importantly, if clonidine is withdrawn while on a beta-blocker, severe rebound hypertension can occur.
How serious is the interaction between Atenolol-chlorthalidone and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are used, monitor heart rate and blood pressure. To stop therapy, withdraw the beta-blocker gradually first, then taper clonidine several days later.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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