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Interactions médicamenteuses

Amiodarone + Clonidine

Gravité: Majeure

Amiodarone and Clonidine: major interaction.

Dernière mise à jour

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Résumé

Both drugs slow heart rate and AV conduction. Used together they can cause marked bradycardia, sinus arrest or AV block, particularly in older patients or those with underlying conduction disease.

Ce que signifie cette interaction, en termes simples

Amiodarone and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Clonidine belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic depression of sinus node and AV nodal function (central sympatholytic effect of clonidine plus amiodarone's antiarrhythmic effects).

Conduite à tenir

Monitor heart rate and ECG at initiation and after dose changes, and avoid the combination in patients with sinus node or AV conduction disease. Never stop clonidine abruptly because of rebound hypertension.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Clonidine?

MediHelp rates the interaction as major. Amiodarone and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow heart rate and AV conduction. Used together they can cause marked bradycardia, sinus arrest or AV block, particularly in older patients or those with underlying conduction disease.

How serious is the interaction between Amiodarone and Clonidine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG at initiation and after dose changes, and avoid the combination in patients with sinus node or AV conduction disease. Never stop clonidine abruptly because of rebound hypertension.

What other medicines interact with Clonidine?

MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amoxapine. The full list is on the Clonidine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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