Interactions médicamenteuses
Adenovirus types 4 and 7 live + Cisplatin
Gravité: Majeure
Adenovirus types 4 and 7 live and Cisplatin: major interaction.
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Résumé
Cisplatin is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine could cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be inadequate.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Chemotherapy-induced immunosuppression impairs control of live attenuated vaccine virus and reduces immune response.
Conduite à tenir
Avoid the live vaccine during cisplatin therapy and for at least 3 months after stopping. Use only when immune recovery is confirmed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cisplatin
- Cidofovir + Cisplatin Contre-indiquée
- Adefovir + Cisplatin Majeure
- Amikacin + Cisplatin Majeure
- Amphotericin b deoxycholate + Cisplatin Majeure
- Amphotericin b + Cisplatin Majeure
- Bacitracin + Cisplatin Majeure
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Cisplatin?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine could cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be inadequate.
How serious is the interaction between Adenovirus types 4 and 7 live and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during cisplatin therapy and for at least 3 months after stopping. Use only when immune recovery is confirmed.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Cisplatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
