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Interactions médicamenteuses

Bacitracin + Cisplatin

Gravité: Majeure

Bacitracin and Cisplatin: major interaction.

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Résumé

Systemic bacitracin (parenteral) is markedly nephrotoxic, and cisplatin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury and increased cisplatin exposure.

Ce que signifie cette interaction, en termes simples

Bacitracin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bacitracin belongs to Miscellaneous; Cisplatin belongs to Oncology.

Niveau de preuve: Low

Pourquoi elle survient

Additive nephrotoxicity from proximal tubular injury.

Conduite à tenir

Avoid concurrent systemic bacitracin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and electrolytes closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bacitracin with Cisplatin?

MediHelp rates the interaction as major. Bacitracin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin (parenteral) is markedly nephrotoxic, and cisplatin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury and increased cisplatin exposure.

How serious is the interaction between Bacitracin and Cisplatin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic bacitracin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and electrolytes closely.

What other medicines interact with Cisplatin?

MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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