Interactions médicamenteuses
Adenovirus types 4 and 7 live + Irinotecan
Gravité: Majeure
Adenovirus types 4 and 7 live and Irinotecan: major interaction.
Dernière mise à jour
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Résumé
Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Cytotoxic immunosuppression impairs the immune response to live attenuated virus, allowing uncontrolled replication and reducing vaccine efficacy.
Conduite à tenir
Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Irinotecan
- Clozapine + Irinotecan Contre-indiquée
- Irinotecan + Sacituzumab govitecan Contre-indiquée
- Apalutamide + Irinotecan Majeure
- Atazanavir + Irinotecan Majeure
- Carbamazepine + Irinotecan Majeure
- Clarithromycin + Irinotecan Majeure
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Irinotecan?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
How serious is the interaction between Adenovirus types 4 and 7 live and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Apalutamide. The full list is on the Irinotecan page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
