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Interactions médicamenteuses

Clarithromycin + Irinotecan

Gravité: Majeure

Clarithromycin and Irinotecan: major interaction.

Dernière mise à jour

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Résumé

Clarithromycin inhibits CYP3A4 and P-glycoprotein, which may increase exposure to irinotecan and its active metabolite SN-38 by diverting it away from inactive pathways. This may worsen neutropenia and diarrhea.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Irinotecan belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 and P-glycoprotein inhibition by clarithromycin alters irinotecan disposition and increases toxic exposure.

Conduite à tenir

Choose a non-interacting antibiotic where possible. If clarithromycin is required, monitor closely for severe diarrhea and myelosuppression and adjust irinotecan as needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Irinotecan?

MediHelp rates the interaction as major. Clarithromycin and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin inhibits CYP3A4 and P-glycoprotein, which may increase exposure to irinotecan and its active metabolite SN-38 by diverting it away from inactive pathways. This may worsen neutropenia and diarrhea.

How serious is the interaction between Clarithromycin and Irinotecan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-interacting antibiotic where possible. If clarithromycin is required, monitor closely for severe diarrhea and myelosuppression and adjust irinotecan as needed.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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