Interactions médicamenteuses
Ado-trastuzumab + Trastuzumab deruxtecan
Gravité: Majeure
Ado-trastuzumab and Trastuzumab deruxtecan: major interaction.
Dernière mise à jour
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Résumé
Both are HER2-directed antibody-drug conjugates with cytotoxic payloads that cause myelosuppression, interstitial lung disease and cardiac toxicity. Combining them duplicates therapy and increases toxicity without established benefit.
Ce que signifie cette interaction, en termes simples
Ado-trastuzumab and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ado-trastuzumab belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Pourquoi elle survient
Additive cytotoxic, myelosuppressive and cardiopulmonary toxicity of two HER2-targeted antibody-drug conjugates.
Conduite à tenir
Avoid concurrent use; they are not intended to be given together. Allow sequential use only with monitoring of blood counts, lung and cardiac function.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ado-trastuzumab
- Ado-trastuzumab + Atazanavir Majeure
- Ado-trastuzumab + Baricitinib Majeure
- Ado-trastuzumab + Ceritinib Majeure
- Ado-trastuzumab + Clarithromycin Majeure
- Ado-trastuzumab + Cobicistat Majeure
- Ado-trastuzumab + Conivaptan Majeure
Autres interactions de Trastuzumab deruxtecan
Questions fréquentes
Can I take Ado-trastuzumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Ado-trastuzumab and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are HER2-directed antibody-drug conjugates with cytotoxic payloads that cause myelosuppression, interstitial lung disease and cardiac toxicity. Combining them duplicates therapy and increases toxicity without established benefit.
How serious is the interaction between Ado-trastuzumab and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; they are not intended to be given together. Allow sequential use only with monitoring of blood counts, lung and cardiac function.
What other medicines interact with Ado-trastuzumab?
MediHelp also lists interactions of Ado-trastuzumab with, for example, Atazanavir, Baricitinib, Ceritinib. The full list is on the Ado-trastuzumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
