Interactions médicamenteuses
Azathioprine + Trastuzumab deruxtecan
Gravité: Majeure
Azathioprine and Trastuzumab deruxtecan: major interaction.
Dernière mise à jour
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Résumé
Trastuzumab deruxtecan commonly causes neutropenia, and azathioprine also suppresses marrow and immune function. Together they may increase the risk of severe neutropenia and infection.
Ce que signifie cette interaction, en termes simples
Azathioprine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Trastuzumab deruxtecan belongs to Oncology.
Pourquoi elle survient
Additive myelosuppression and immunosuppression from the cytotoxic topoisomerase I inhibitor payload and azathioprine's antimetabolite effect.
Conduite à tenir
Monitor complete blood counts before each trastuzumab deruxtecan dose and watch for fever or infection. Consider reducing or stopping azathioprine if neutropenia develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contre-indiquée
- Azathioprine + Bcg vaccine live Contre-indiquée
- Azathioprine + Febuxostat Contre-indiquée
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine live Contre-indiquée
Autres interactions de Trastuzumab deruxtecan
Questions fréquentes
Can I take Azathioprine with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Azathioprine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan commonly causes neutropenia, and azathioprine also suppresses marrow and immune function. Together they may increase the risk of severe neutropenia and infection.
How serious is the interaction between Azathioprine and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each trastuzumab deruxtecan dose and watch for fever or infection. Consider reducing or stopping azathioprine if neutropenia develops.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
