Interactions médicamenteuses
Alfentanil + Diazepam
Gravité: Majeure
Alfentanil and Diazepam: major interaction.
Dernière mise à jour
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Résumé
Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
Ce que signifie cette interaction, en termes simples
Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression via GABA-A and opioid receptor activity.
Conduite à tenir
Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Diazepam
- Calcium / magnesium / potassium / sodium oxybates + Diazepam Contre-indiquée
- Alprazolam + Diazepam Majeure
- Amobarbital + Diazepam Majeure
- Belladonna and opium + Diazepam Majeure
- Benzhydrocodone / acetaminophen + Diazepam Majeure
- Brexanolone + Diazepam Majeure
Questions fréquentes
Can I take Alfentanil with Diazepam?
MediHelp rates the interaction as major. Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
How serious is the interaction between Alfentanil and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alprazolam, Amobarbital. The full list is on the Diazepam page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
