Interactions médicamenteuses
Benzhydrocodone / acetaminophen + Diazepam
Gravité: Majeure
Benzhydrocodone / acetaminophen and Diazepam: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
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Résumé
Benzodiazepines combined with opioids can cause profound sedation, respiratory depression, coma and death, and this is a boxed warning for opioid products. Benzhydrocodone is a hydrocodone prodrug, so the risk matches other opioids.
Ce que signifie cette interaction, en termes simples
Benzhydrocodone / acetaminophen and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression from GABA-A potentiation and mu-opioid agonism.
Conduite à tenir
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Diazepam
- Calcium / magnesium / potassium / sodium oxybates + Diazepam Contre-indiquée
- Alfentanil + Diazepam Majeure
- Alprazolam + Diazepam Majeure
- Amobarbital + Diazepam Majeure
- Belladonna and opium + Diazepam Majeure
- Brexanolone + Diazepam Majeure
Questions fréquentes
Can I take Benzhydrocodone / acetaminophen with Diazepam?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids can cause profound sedation, respiratory depression, coma and death, and this is a boxed warning for opioid products. Benzhydrocodone is a hydrocodone prodrug, so the risk matches other opioids.
How serious is the interaction between Benzhydrocodone / acetaminophen and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
