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Interactions médicamenteuses

Alprazolam + Diazepam

Gravité: Majeure

Alprazolam and Diazepam: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Taking two benzodiazepines together gives duplicate therapy with additive sedation, psychomotor impairment, memory problems and respiratory depression. Risk of dependence and falls is also increased, especially in older adults.

Ce que signifie cette interaction, en termes simples

Alprazolam and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Alprazolam belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Additive GABA-A receptor potentiation producing CNS depression.

Conduite à tenir

Avoid concurrent use of two benzodiazepines; consolidate to a single agent at the lowest effective dose. If a switch is needed, taper one drug gradually.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Alprazolam with Diazepam?

MediHelp rates the interaction as major. Alprazolam and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two benzodiazepines together gives duplicate therapy with additive sedation, psychomotor impairment, memory problems and respiratory depression. Risk of dependence and falls is also increased, especially in older adults.

How serious is the interaction between Alprazolam and Diazepam?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines; consolidate to a single agent at the lowest effective dose. If a switch is needed, taper one drug gradually.

What other medicines interact with Diazepam?

MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Amobarbital. The full list is on the Diazepam page.

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