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Interactions médicamenteuses

Aliskiren + Losartan

Gravité: Contre-indiquée

Aliskiren and Losartan: contraindicated interaction.

Dernière mise à jour

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Résumé

Combining an angiotensin receptor blocker with aliskiren produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment, including acute kidney injury, without added outcome benefit. The combination is contraindicated in patients with diabetes and should be avoided in renal impairment.

Ce que signifie cette interaction, en termes simples

Aliskiren and Losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Aliskiren belongs to Cardiovascular; Losartan belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic blockade of the renin-angiotensin-aldosterone system at two different points.

Conduite à tenir

Do not co-prescribe in patients with diabetes or with GFR below 60 mL/min; avoid in others where possible. If ever used, monitor blood pressure, potassium and creatinine closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aliskiren with Losartan?

MediHelp rates the interaction as contraindicated. Aliskiren and Losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an angiotensin receptor blocker with aliskiren produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment, including acute kidney injury, without added outcome benefit. The combination is contraindicated in patients with diabetes and should be avoided in renal impairment.

How serious is the interaction between Aliskiren and Losartan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe in patients with diabetes or with GFR below 60 mL/min; avoid in others where possible. If ever used, monitor blood pressure, potassium and creatinine closely.

What other medicines interact with Losartan?

MediHelp also lists interactions of Losartan with, for example, Sparsentan, Amifostine, Amiloride. The full list is on the Losartan page.

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