Interactions médicamenteuses
Amifostine + Losartan
Gravité: Majeure
Amifostine and Losartan: major interaction.
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Résumé
Amifostine commonly causes hypotension, and antihypertensives such as losartan can worsen the fall in blood pressure. At chemotherapeutic doses of amifostine, severe hypotension is a concern.
Ce que signifie cette interaction, en termes simples
Amifostine and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amifostine belongs to Miscellaneous; Losartan belongs to Cardiovascular.
Pourquoi elle survient
Additive pharmacodynamic hypotensive effects of the two drugs.
Conduite à tenir
For chemotherapeutic amifostine doses, withhold losartan for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely and ensure hydration.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Losartan
- Aliskiren + Losartan Contre-indiquée
- Losartan + Sparsentan Contre-indiquée
- Amiloride + Losartan Majeure
- Amlodipine-benazepril + Losartan Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Majeure
- Amlodipine-olmesartan-hydrochlorothiazide + Losartan Majeure
Autres interactions de Amifostine
- Aldesleukin + Amifostine Majeure
- Alfuzosin + Amifostine Majeure
- Amifostine + Amlodipine Majeure
- Amifostine + Amlodipine-atorvastatin Majeure
- Amifostine + Amlodipine-benazepril Majeure
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Majeure
Questions fréquentes
Can I take Amifostine with Losartan?
MediHelp rates the interaction as major. Amifostine and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amifostine commonly causes hypotension, and antihypertensives such as losartan can worsen the fall in blood pressure. At chemotherapeutic doses of amifostine, severe hypotension is a concern.
How serious is the interaction between Amifostine and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For chemotherapeutic amifostine doses, withhold losartan for 24 hours beforehand; if it cannot be withheld, do not give amifostine. At lower radioprotective doses, monitor blood pressure closely and ensure hydration.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amiloride. The full list is on the Losartan page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
