Interactions médicamenteuses
Amlodipine-olmesartan-hydrochlorothiazide + Losartan
Gravité: Majeure
Amlodipine-olmesartan-hydrochlorothiazide and Losartan: major interaction.
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Résumé
Combining losartan with a product that already contains olmesartan means two angiotensin receptor blockers are used together. This gives no meaningful added benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
Ce que signifie cette interaction, en termes simples
Amlodipine-olmesartan-hydrochlorothiazide and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Pourquoi elle survient
Duplicate angiotensin II type 1 receptor blockade produces additive hypotensive, renal and potassium-retaining effects.
Conduite à tenir
Avoid concurrent use of two angiotensin receptor blockers and discontinue one of them. If an overlap occurs, check blood pressure, serum potassium and creatinine.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contre-indiquée
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contre-indiquée
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contre-indiquée
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Majeure
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Majeure
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Majeure
Autres interactions de Losartan
- Aliskiren + Losartan Contre-indiquée
- Losartan + Sparsentan Contre-indiquée
- Amifostine + Losartan Majeure
- Amiloride + Losartan Majeure
- Amlodipine-benazepril + Losartan Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Majeure
Questions fréquentes
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Losartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining losartan with a product that already contains olmesartan means two angiotensin receptor blockers are used together. This gives no meaningful added benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two angiotensin receptor blockers and discontinue one of them. If an overlap occurs, check blood pressure, serum potassium and creatinine.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
