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Interactions médicamenteuses

Allopurinol + Ampicillin-sulbactam

Gravité: Modérée

Allopurinol and Ampicillin-sulbactam: moderate interaction.

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Résumé

Patients taking allopurinol and ampicillin have shown a higher rate of skin rash than with either drug alone. Rash is usually mild but can obscure or be mistaken for a serious hypersensitivity reaction.

Ce que signifie cette interaction, en termes simples

Allopurinol and Ampicillin-sulbactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Allopurinol belongs to Genitourinary; Ampicillin-sulbactam belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Mechanism unknown; possibly additive hypersensitivity or an effect of hyperuricemia on rash.

Conduite à tenir

Counsel patients to report any rash promptly and stop the drugs if rash is severe or accompanied by fever, mucosal lesions or blistering; consider an alternative antibiotic if feasible.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Allopurinol with Ampicillin-sulbactam?

MediHelp rates the interaction as moderate. Allopurinol and Ampicillin-sulbactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients taking allopurinol and ampicillin have shown a higher rate of skin rash than with either drug alone. Rash is usually mild but can obscure or be mistaken for a serious hypersensitivity reaction.

How serious is the interaction between Allopurinol and Ampicillin-sulbactam?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report any rash promptly and stop the drugs if rash is severe or accompanied by fever, mucosal lesions or blistering; consider an alternative antibiotic if feasible.

What other medicines interact with Ampicillin-sulbactam?

MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin-sulbactam page.

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